How Do GLP-1 and GIP Analogues Work for Weight Loss?
Understanding the Difference Between Tirzepatide (Mounjaro) and Semaglutide (Wegovy/Ozempic)
Medications like Semaglutide (Wegovy/Ozempic) and Tirzepatide (Mounjaro) have transformed the landscape of medical weight loss. These once-weekly injections are now widely prescribed to help patients lose weight effectively — especially when traditional methods haven’t worked.
At Niva Medical Clinic, we offer medically supervised weight loss plans using the latest, evidence-based treatments. But what do these medications actually do — and which one might be right for you?
What Are GLP-1 and GIP Hormones?
GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) are naturally occurring gut hormones that help regulate blood sugar and appetite. After a meal, they:
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Signal fullness to the brain
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Slow down digestion
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Boost insulin production
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Help stabilise blood sugar levels
GLP-1 analogues like Semaglutide, and dual GIP/GLP-1 analogues like Tirzepatide, mimic these hormones to support weight loss and blood sugar control.
Semaglutide (Wegovy/Ozempic) – GLP-1 Analogue
Semaglutide, branded as Wegovy or Ozempic, mimics GLP-1 to suppress appetite and promote weight loss. It’s taken once a week as a subcutaneous injection.
Key Benefits:
– Reduced hunger and calorie intake
– Improved blood sugar regulation
– Promotes weight loss when combined with diet and activity
A landmark clinical trial — the STEP 1 study — showed that participants lost an average of 14.9% of body weight over 68 weeks with Semaglutide:
🔗 Read the study in The New England Journal of Medicine (2021)
Tirzepatide (Mounjaro) – Dual GLP-1 and GIP Analogue
Tirzepatide, branded as Mounjaro, is a dual hormone agonist — meaning it mimics both GLP-1 and GIP, offering a more potent effect on metabolism and appetite.
Key Benefits:
– Stronger appetite suppression
– Enhanced insulin sensitivity and fat burning
– Greater weight loss in clinical trials
The SURMOUNT-1 study showed an average weight loss of 15–20.9% depending on the dose:
🔗 Read the study in The New England Journal of Medicine (2022)
Mounjaro vs Wegovy – Key Differences
| Feature | Wegovy/Ozempic (Semaglutide) | Mounjaro (Tirzepatide) |
|---|---|---|
| Hormones targeted | GLP-1 | GLP-1 + GIP |
| Frequency | Weekly injection | Weekly injection |
| Weight loss (avg) | ~15% | Up to 20%+ |
| Approved use (UK) | Obesity & weight management | Type 2 diabetes & Obesity |
| Mechanism | Appetite reduction & slower digestion | Dual-action: hunger suppression + enhanced metabolism |
| Side effects | Nausea, bloating, constipation | Similar, may be slightly stronger GI effects |
How Niva Medical Clinic Differs from Online Weight Loss Injection Services
With many online services now offering fast prescriptions for weight loss injections, it’s important to understand the risks of remote-only care.
Here’s how Niva Medical Clinic offers a safer, more personalised alternative:
✔️ In-depth, face-to-face assessments — including blood tests, BMI, and metabolic markers
✔️ Ongoing monitoring by experienced GPs
✔️ Lifestyle coaching and nutritional guidance
✔️ Medication only prescribed when clinically appropriate
✔️ Local, trusted care with real doctors who know you
Weight loss is not just about injections — it’s about long-term health. We focus on sustainable, holistic care that addresses your body and mind.
Serving North West London & Hertfordshire
We welcome patients from Stanmore, Harrow, Watford, Bushey, Borehamwood, Hatch End, Northwood, Pinner, Barnet, Wembley, Kingsbury, and St Albans.
Ready to Take Control of Your Weight and Health?
If you’re considering Semaglutide (Wegovy/Ozempic) or Tirzepatide (Mounjaro), we’re here to help.
📞 Call us on 020 8865 1938
Book online today
Let’s work together towards sustainable, healthy weight loss — with expert care at every step.
